Onset Injection
Onset Injection is an antiemetic medication that prevents nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy. It works by blocking serotonin (5-HT3) receptors in the brain and gastrointestinal tract, reducing the signals that trigger nausea and vomiting. The injection is a clear, colorless solution packaged in single-use vials, ensuring safe and hygienic administration.
- Manufactured By: Pharmadic
- Generic: Ondansetron
- Drug Class: Antiemetic (5-HT3 Receptor Antagonist)
- Available Strengths: 4 mg/2 mL and 8 mg/4 mL
- Price: PKR 180-200
- (1 Pack = 1 Ampule Injection)
Onset Injection Uses
Onset Injection is prescribed for the prevention of nausea and vomiting in the following cases:
- Associated with Highly Emetogenic Cancer Chemotherapy (HEC)
- Associated with Moderately Emetogenic Cancer Chemotherapy (MEC)
- As part of a Combination Therapy for Post-Operative Nausea and Vomiting
- Related to Radiotherapy in Specific Conditions
Dosage
The dosage of Onset Injection depends on the type and intensity of chemotherapy and the patient’s condition. It should be administered as directed by a healthcare provider, typically through intravenous (IV) injection or infusion.
How to Use Onset Injection
- It is given intravenously, either as a bolus injection or diluted for infusion.
- Timing and dosage are important; follow the recommended schedule provided by your doctor.
- Ensure the injection site is clean and sterilized to avoid infections.
- The injection should be inspected visually for particulate matter or discoloration before administration; do not use it if either is observed.
- Follow-up monitoring may be necessary after administration to observe for potential side effects or effectiveness.
Onset Injection Side Effects
Onset Injection may cause side effects in some individuals. It is important to notify your doctor if any of the following occur.
- Injection Site Reactions (Pain, Redness, or Swelling)
- Flushing or Warmth Sensation
- Constipation
- Headache
- Dizziness
- Hiccups
- Fatigue
Warnings Associated with Onset Injection
Certain precautions must be taken for the safe use of Onset Injection:
- Inform your doctor of any history of hypersensitivity to ondansetron or other 5-HT3 antagonists.
- Use cautiously in patients with severe hepatic impairment.
- Not recommended for use in children under 6 months of age.
- May interact with other medications, such as apomorphine or CYP450 inducers.
- Monitor for signs of serotonin syndrome if used alongside serotonergic drugs.
Storage
- Store at room temperature below 30°C.
- Protect from light and freezing.
- Keep out of reach of children.
FAQs
1. What is the price of Onset Injection in Pakistan?
The price of Onset Injection in Pakistan generally ranges from 180-200PKR per box of 1 ampule injection. Prices may vary depending on the pharmacy and location.
2. What is the use of Onset Injection in Urdu?
انسٹ انجیکشن کا استعمال کیموتھراپی کے دوران متلی اور قے کی روک تھام کے لئے کیا جاتا ہے۔ یہ دوا دماغ اور معدے میں سیروٹونن ریسیپٹرز کو بلاک کر کے متلی اور قے کے سگنلز کو کم کرتی ہے.
3. Is Onset Injection safe during pregnancy?
Onset Injection should be used during pregnancy only if clearly needed and prescribed by a healthcare provider. Discuss potential risks and benefits with your doctor.
